Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma
The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole (18F-FRP170).
Twelve patients with glioblastoma underwent 18F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of 18F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.
Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.
The present findings suggest that high accumulation on 18F-FRP170 PET represents viable hypoxic tissues in glioblastoma.
Takaaki Beppu1 , Kazunori Terasaki2, Toshiaki Sasaki2, Shunrou Fujiwara1, Hideki Matsuura1, Kuniaki Ogasawara1, Koichiro Sera2, Noriyuki Yamada3, Noriyuki Uesugi3, Tamotsu Sugai3, Kohsuke Kudo4, Makoto Sasaki4, Shigeru Ehara5, Ren Iwata6 and Yoshihiro Takai7
(1)Department of Neurosurgery, Iwate Medical University, Uchimaru 19-1, Morioka 020-8505, Japan
(2)Cyclotron Research Center, Iwate Medical University, Morioka, Japan
(3)Department of Clinical Pathology, Iwate Medical University, Morioka, Japan
(4)Institute for Biomedical Sciences, Iwate Medical University, Morioka, Japan
(5)Department of Radiology, Iwate Medical University, Morioka, Japan
(6)Cyclotron and Radioisotope Center (CYRIC), Tohoku University, Sendai, Japan
(7)Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan