2017 Educational Sessions

Educational Session 1: Temperature-sensitive Drug Carriers and Ultrasound (UMIDD)

Wednesday, September 13, 2017 | 9:00-10:30

Ultrasound can be used in many different ways to accomplish image guided, local drug delivery. In this session we focus on the combination of local hyperthermia together with temperature sensitive drug nanocarriers. Such nanocarriers, in particular temperature sensitive liposomes, have been suggested more than 30 years ago. This field has recently gained attention because of progress in noninvasive local hyperthermia based on Focused Ultrasound, as well as new nanocarrier formulations. When temperature sensitive liposomes enter a region with a temperature near or above the critical temperature of such liposomes, a burst intravascular drug release takes place providing the driving force for extravasation and intracellular uptake. In this session, attention will be paid to the formulation aspects, the drug release process, preclinical and clinical applications. It will be shown how molecular imaging is used for validation, pharmacokinetics and pharmacodynamics.

Speakers:

  • Mark Dewhirst –

    Talk title: Opportunities and Threats to Use of Thermosensitive Drug Carrying Liposomes

  • Kathy Ferrara –

    Talk title: Enhanced Drug and Gene Delivery With Ultrasound

  • Holger Gruell –

    Talk title: MR-HIFU for image-guided local drug delivery using temperature sensitive liposomes

 

Educational Session 2: Advancing Imaging Technologies and Applications to Impact Drug Discovery and Development

Wednesday, September 13, 2017 | 9:00-10:30

Advancing Imaging Technologies and Applications to Impact Drug Discovery and Development

Speakers: 

  • Stephen Castellino –

    Talk title: Molecular Visualization in Tissues by MALDI Imaging MS: Applications in Drug Discovery and Development

  • Eric Messina –

    Talk title: Novel Applications of Imaging Toward Assessment of Drug Induced Vascular Injury (DIVI)

  • Michael Rosol –

    Talk title: Deploying New Imaging Readouts in Humans: Connecting Preclinical and Clinical Imaging

 

Educational Session 3: NeuroPET: Applications in Drug Development and the Study of Neurodegeneration

Wednesday, September 13, 2017 | 9:00-10:30

Positron Emission Tomography (PET) is an in vivo imaging technique that measures the uptake and clearance rates of a PET radiotracer in tissue.  From this information, it is possible to obtain valuable information on the endogenous molecule targeted by the PET radiotracer.  For brain imaging studies, these targets have traditionally been neurotransmitter receptors or enzymes which become dysregulated in neurological or neuropsychiatric disorders, or aggregated misfolded proteins which are a hallmark feature of neurodegenerative disorders such as Alzheimer’s disease.  A more recent application of this imaging technique is the use of PET-based versions of CNS-active drugs as a means of measuring target engagement or pharmacokinetics of the drug to its protein of interest.  This information can be useful in selecting candidates that are likely to show efficacy in a phase 1 clinical trial.  In this session, attention will be paid to three different aspects of NeuroPET imaging studies, including the identification of a suitable lead compound for the development of a PET probe for studying CNS function, the use of PET to study the role of neuroinflammation in neurodegeneration, and microdosing techniques with PET-based versions of a CNS active drug in the drug evaluation process.

Speakers:

  • Eric Hostetler –

    Talk title: PET Imaging in Neuroscience Drug Development: Target Engagement and Beyond

  • Victor Pike –

    Talk title: Radiotracer development for PET investigations of neuroinflammation

  • Robert Mach –

    Talk title: Conversion of a Fluorescent Probe to a PET Radiotracer: Application in the Development of CNS Probes

 

Educational Session 4: Chemistry – Things I Should Know but Afraid to Ask

Wednesday, September 13, 2017 | 11:00-12:30

A discussion and look into the challenging areas of chemistry and a perspective on things researchers should know.

Speakers:

  • Matthew Bogyo –

    Talk title: New chemical probe technologies: how chemistry can be used for medical imaging and drug discovery

  • Richard Silverman –

    Talk title: CPP-115: A Novel GABA Aminotransferase Inactivator and Potential New Treatment for Epilepsy, Addiction, and Hepatocellular Carcinoma

Educational Session 5: Computation and Modeling for Better Imaging (AAPM)

Wednesday, September 13, 2017 | 11:00-12:30

The American Association of Physicists in Medicine (AAPM) and the World Molecular Imaging Society (WMIS) will host year’s symposium and discuss topics in the are of  Computation and Modeling for better imaging with speakers such speakers as Ben Cox, Chad Quarles and Richard Carson.

Speakers:

  • Ben Cox –

    Talk title: Multiwavelength Quantitative Photoacoustic Imaging

  • Chad Quarles –

    Talk title: Imaging tissue microstructure using quantitative susceptibility based contrast enhanced MRI

  • Richard Carson –

    Talk title: Quantification Strategies for PET Imaging: Challenges and Opportunities

 

Educational Session 6: Navigating the Transition from Graduate Student to Postdoctoral Fellow (ESPMIS)

Wednesday, September 13, 2017 | 11:00-12:30

This year, ESPMIS will provide an educational career-development session focused on one of the most important times in a young scientist’s career: the transition from graduate student to postdoctoral fellow. The session is headlined by three presentations focused different aspects of this topic: choosing a postdoctoral mentor (Prof. Nerissa Viola-Villegas, Wayne State University), shaping your postdoctoral fellowship for your future career (Dr. Julien Dimastromatteo, University of Virginia), and the choice between academia and industry (Dr. Kiel Neumann, University Virginia). In addition, we will be hosting a panel discussion entitled “The Promise and Pitfalls of an International Post-Doc” that will provide an entertaining and diverse set of viewpoints on the advantages and disadvantages of traveling abroad for postdoctoral fellowships.

Speakers:

  • Nerissa Viola-Villegas –

    Talk title: How to Spend “X” Years of Your Life Post-PhD

  • Julien Dimastromatteo –

    Talk title: Tailoring Your Post-Doc for the Job You Want

  • Kiel Neumann –

    Talk title: Academia or Industry; Which Would You Choose?

  • Panelists – “The Promise and Pitfalls of an International Post-Doc”
    EricPrice
    GiuseppeCarlucci
    PatrickMcCormick
    Tanushree(Nina)Ganguly